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The most promising indazole compound 15 exhibited an IC 50 of 6 nM toward AT1 receptor and modulated PPAR activity with an EC 50 of 250 nM

Conclusion In summary, our results confirm the efficacy of XYP injection in alleviating IAV infection in mice, as evidenced by reductions in mortality, weight loss, lung injury, and viral load

2 , 3 According to self-reported data from the 2022 Canadian Community Health survey, close to one in three Canadian adults are living with obesity

Additionally, VC inhibits HIF1a transcription and increases HIF1 alpha-hydroxylase activity, leading to mitochondrial activation (115) and antioxidant effects

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