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3.3 Cyclophosphamide CYC is a well-established alkylating agent widely used in the treatment of severe manifestations of SLE, particularly lupus nephritis (LN) (Zhang et al., 2014)

Distinct p53-mediated G1/S checkpoint responses in two NIH3T3 subclone cells following treatment with DNA-damaging agents

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A 2.5 mg track has short direct data and real-world support for stable maintainers, but continuing tirzepatide has much stronger evidence than stopping. At week 112, stepping down to 5 mg preserved 16.6% weight loss versus 21.9% on the top dose and 9.9% on placebo