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47,48,49 Nevertheless, more research is needed to prove the hypothesis, and perhaps, in the near future, our understanding of the classical model will be expanded or even subverted

In the brain, GLP-1 receptor activation affects areas that regulate appetite and satiety, leading to reduced hunger and increased feelings of fullness

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There was no change in TBR (reported as the percentage of time spent with interstitial glucose values below 70 mg/dL), whereas a severe hypoglycemic episode ( n = 1) and severe constipation ( n = 1) led to tirzepatide discontinuation in two patients

2009 Feb;47(2):81-8.

Surgery GLP-1 drugs mimic at least one hormone produced by the gut to signal fullness, leading to a reduced appetite