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10.1007/s43032-022-01038-2 76 ZhangH.YangB.ZhangP.CaoJ.ZhangX.GahallahS.et al (2025)

It is also effective in reducing the appearance of dark spots, wrinkles, or acne marks

Safety is paramount when considering any skincare regimen

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Metal chelation Redox-active metal ions, such as free iron and copper, can induce oxidative damage by catalyzing reactions that generate highly reactive free radicals (20)

Estradiol has a strong and long-binding affinity at the estrogen receptors and is responsible for most cell proliferation at estrogen-sensitive tissues, such as breast and uterine tissues, in menstruating women