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Evaluation of anxiolytic properties of Gotukola(Centella asiatica) extracts and asiaticoside in rat behavioral models

Results Inhibition of glutathione metabolism depletes neuronal glutamate and affects excitatory transmission To test the hypothesis that glutathione is a significant reservoir for glutamate, we treated neuronal cells with molecular inhibitors targeting enzymes of the glutathione metabolic cycle: L-2-imidazolidone-4-carboxylate (2I4C), acivicin, L-buthionine sulfoximine (BSO), and sulforaphane

For example, Fusobacterium necrophorum can induce necrotizing stomatitis through the secretion of toxins and proteolytic enzymes, resulting in fever, severe ulceration, and marked reductions in feed intake

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