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347 This was achieved by decreasing the expression of proinflammatory cytokines such as tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8)

doi: 10.1016/j.bbrc.2017.06.031 63 SammsRJCoghlanMPSloopKW

Additionally, Novo Nordisk sells a pill form of semaglutide, under the brand name Rybelsus, for treating type 2 diabetes

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Therefore, in combined use with endostatin, the VEGFR2-blocking, human anti- VEGF antibodies of the invention will neutralize VEGF and amplify the anti-tumor effects of endostatin

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