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doi: 10.1056/NEJMra0901217 120 HsuR.-J.YuW.-C.PengG.-R.YeC.-H.HuS

Each ingredient was administered to human keratinocytes alone or in combination

[2] The study was not controlled for cream vehicle application alone without active ingredients

Mycotoxins disrupt this barrier primarily by reducing the expression of tight junction (TJ) proteins, including claudins and occludin (171), often mediated by increased levels of pro-inflammatory cytokines such as TNF- and IL-6 (172)

Lipid metabolism may also be involved in oxidative stress- and mitochondrial dysfunction-induced increase in vascular permeability

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