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Intrarectal instillation of AA is followed by protonation and migration of molecule of AA into colonic microflora, resulting in destruction of colonic epithelium, increased bacterial influx into the lamina propria, and enhancement of the activated enterocytes to generate a variety of cytokines (Soliman et al

PMID: 36839371

Therefore, as a result, NRF2 activator is viewed as a promising medication for boosting antioxidant defences and reducing pathology