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While the peptide appeared well tolerated in these trials, the absence of reproducible clinical benefit meant the molecule did not progress to approval or further late-stage studies

Future research should include well-designed comparative studies to clarify the relative efficacy and safety of these related healing and regenerative peptides

10.3390/molecules21030356 Summary Keywords alopecia, cacumen platycladi, hair follicles, dermal papilla cells, Akt, GSK3 Citation Fu H, Li W, Weng Z, Huang Z, Liu J, Mao Q and Ding B (2023) Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3/-catenin signaling pathway

Antioxidants 10(6):967 Wells G, Shea B, OConnell D, Peterson J, Welch V, Losos M, Tugwell P (2021) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

GSH is readily oxidized to its disulfide form (GSSG), which can be transformed back to its GSH form, by reduced nicotinamide adenine dinucleotide phosphate (NADPH) and the FAD-dependent glutathione reductase (GR)