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Some women may need only one or two treatments during their entire pregnancy, while others with severe hyperemesis gravidarum may require more frequent sessions

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Following cerebral ischemia, the substantial release of various cytokines, chemokines and damage-associated molecular patterns (DAMPs) attributes to the activation and recruitment of neutrophils from the bone marrow, spleen, and peripheral circulation to the site of damage ( Table 2 )

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In a dominant lethal assay, a single intraperitoneal injection of 176 mg DCA/kg in male mice (AB Jena-Halle strain) produced a decrease in the number of total implants and live fetuses in the first 3 weeks of the test, and an increase in post-implantation losses