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Moreover IR in PCOS was shown to destroy the effect of gonadotropins, enhance the sensitivity of follicular membrane cells to the luteinizing hormone, and increase the expression of P450c17 and 3-hydroxysteroid dehydrogenase type 2, leading to increased production of androgen (152)

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They share a class mechanism and a broadly similar side effect profile, but their approved uses, dose ranges, and molecular structures are meaningfully different