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Tirzepatide initiation was actually associated with a lower overall risk of joint pain, including lower back pain, hip pain, and knee pain

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At the time this clinical data was collected in 2017, dulaglutide was the only once-weekly GLP-1 receptor agonist available

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Disturbances of this metabolic interaction between astrocytes and neurons will affect GSH homeostasis in brain and could contribute to a compromised antioxidative defense in neurological diseases