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Its mature domain binds and activates the type 1 IGF receptor (IGF-1R), triggering the canonical downstream cascades principally the PI3K/Akt/mTOR axis that governs protein synthesis and the Ras/ERK axis associated with proliferation

And in many cases, their physical transformations are visually remarkable

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[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Tanaka Y., Ito T., Kaku-Ito Y., Tanegashima K., Tsuji G., Kido-Nakahara M., Oda Y., Nakahara T

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How the Findings Fit Together The VEGFR2, Src, FAK, ERK1/2, and FBXO22 studies were not all performed in the same cells or under the same conditions