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These pathways include anti-apoptotic proteins, metabolic regulators, and inflammatory mediators, as illustrated in Inhibition of Anti-Apoptotic Pathways: The BCL-2 family regulates apoptosis, and senescent cells often exhibit increased expression of anti-apoptotic (pro-survival proteins) proteins such as BCL-2, BCL-XL, and BCL-W

The compound enhances FAK autophosphorylation at Y397, creating high-affinity binding sites for Src family kinases

STEP-4 trial data demonstrated 14% body weight rebound following Wegovy discontinuation at 68 weeks , establishing clinical justification for long-term GLP-1 therapy that insurers and national health technology bodies are progressively incorporating into obesity management protocols

Longo, G.V

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IH and CR carried out the data preparation and the statistical analysis and AG-S drafted the manuscript