Disclosure of interest: Xiao Wang: nothing to disclose E-Posters - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P2515 - ESOC25-1203 GUT MICROBIOTADEPENDENT TRIMETHYLAMINE N-OXIDE AND COGNITIVE FUNCTION OVER THREE YEARS AFTER MILD-TO MODERATE ISCHEMIC STROKE - PROSCIS B Thomas Liman 1 , Naomi Giesers 2 , Arash Haghikia 3 , Ulf Landmesser 4 , Stanley Hazen 5 , Matthias Endres 6 1 University of Oldenburg, Charit Universittsmedizin Berlin, Oldenburg, Germany, 2 University of Oldenburg, Oldenburg, Germany, 3 Ruhr University Bochum, Bochum, Germany, 4 Charit Universittsmedzin Berlin, Berlin, Germany, 5 Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, United States, 6 Charit Universittsmedizin Berlin, Dept of neurology, Berlin, Germany Background and Aims: Gut microbiotadependent metabolites, in particular trimethylamine n-oxide (TMAO) have been identified as promoters of atherosclerosis

GLP-1 receptor agonists can delay gastric emptying, potentially affecting the absorption of oral medications
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The addition of extended-release nicotinic acid to simvastatin prevented the increase in CIMT compared to simvastatin monotherapy
Common side effects The most frequently reported effects during semaglutide research include gastrointestinal symptoms
Many of the men in the overweight category will have enlarged male breasts (another term for gynecomastia) that will have to be managed after weight loss with semaglutide and other weight loss medications