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DSIP has since become a research tool for laboratory investigation of sleep architecture, hypothalamicpituitaryadrenal (HPA) axis modulation, and neuroendocrine stress response

The eight-week persistence of effects after treatment discontinuation is particularly noteworthy

Patients must be clearly informed of the risks associated with nonFDA-approved products, including potential contamination, inaccurate dosing, variable bioactivity, and the presence of impurities that may provoke adverse or unpredictable effects

Its not an absolute contraindication unless the issue is directly related to copper metabolism, but it does require careful consideration

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