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Again, the findings backed up the idea that these genetic variants lead to GLP-1 resistance: Those who had the standard PAM gene variants reacted better to GLP-1 medication than those who didn't

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The role of Arc in synaptic plasticity and memory is complex and manifold (Nikolaienko et al., 2018) but one important function at synapses is to promote internalization of AMPARs and LTD via interaction with other post-synaptic proteins such as endophilin/dynamin (Okuno et al., 2012

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