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Extreme caution is advised in patients with epilepsy, advanced age, or chronic pulmonary disease because hypoxia and acidosis lower the seizure threshold and potentiate cardiotoxicity

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Nrf2 exerts antiapoptotic effects by increasing the antioxidant capacity and controlling apoptosis-related gene expression

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Adequate protein intake and resistance training are the standard clinical recommendations for preserving lean mass during GLP-1 treatment

A subsequent cross-sectional study by Yekta et al