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This simply means you will "start low and go slow." You begin with a small introductory dose and gradually increase it over weeks or even months
The 2.5 mg dose provides submaximal receptor engagement and the weight loss effect of tirzepatide at therapeutic doses typically becomes apparent after reaching 5 mg or 10 mg, usually around week 8 to 12
Regarding AV blocks, semaglutide significantly reduced complete AV block (RR 0.22, 95% CI 0.06 to 0.80) ( Supplementary Figure 1E ) but had no significant effect on first-degree (RR 1.60, 95% CI 0.20 to 13.01) ( Supplementary Figure 2F ) or second-degree AV block (RR 0.64, 95% CI 0.23 to 1.80) ( Supplementary Figure 1G )
The location itself does not determine the diagnosis, but it does mean you are more likely to notice changes early, which is actually an advantage from a monitoring perspective