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It was first isolated in human plasma in 1973, and subsequent decades of research have revealed a mechanism that goes considerably beyond simple collagen stimulation

Kumar, A

Eu J Pharmacol 2007

ROS accumulation disrupts insulin signaling by inhibiting insulin receptor substrate (IRS) proteins, which subsequently reduces the translocation of glucose transporter type 4 (GLUT4) to the plasma membrane and lowers glucose uptake in peripheral tissues such as muscle and adipose tissue

Lesions were found adhering to the peritoneal wall, in the abdominal fat pad, and in the intestinal mesentery, at comparable frequencies between the diet groups

Electrospray ionization mass spectrometry (ESI-MS) was applied to investigate the mass of the desired compounds