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Conversion was calculated at each timepoint as previously reported according to the equation: where [ S ] 0 is the initial substrate concentration, X is the emission at 470 nm:emission at 526 nm (Em470:Em526) at a given timepoint, neg is the Em470:Em526 from protease-free substrate control at the same timepoint, and pos is the Em470:Em526 ratio upon complete conversion (trypsinolysis)

To our knowledge, this is one of the first prospective case-control studies focusing exclusively on female FM patients

Supplementation with riboflavin can act as a molecular chaperone, restoring structure and improving function in FAD-domain mutants (71)

Yes, glutathione works very well when paired with other antioxidants like Vitamin C and Vitamin E

Given this patient's concurrent MDS and PH, therapeutic phlebotomy was not feasible

A missed dose does not break the cycle