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Heres a realistic timeline for both therapies: Overall Timeline for Sermorelin: 12 weeks: Better sleep and mood 46 weeks: Increased energy and mild body composition shifts 36 months: Lean mass gains, improved recovery, fat loss Overall Timeline for Tesamorelin: 24 weeks: Noticeable visceral fat reduction 3 months: Metabolic health markers improve 6 months: Peak fat loss

10.1001/jama.2017.18391 JAMA

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doi: 10.18632/aging.204933 176 ChenJYangLHaoXHeQHouSJ

Additionally, GLP-1 analogs reduced energy expenditure, with only tirzepatide showing a significant decrease in the respiratory quotient (RQ) in MC4R KO mice