SOD and CAT are key antioxidant enzymes that maintain redox balance within cells (Pudlarz et al., 2020)
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Why it matters Big Pharma is leaning into novel immunology modalities (molecular glues, oral IL-23R, OX40/OX40L)
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Further study is needed, but this could be the tie that binds the two disorders together
Recent pre-clinical evidence including those from our research group demonstrate that administration of ALA results in H 2 S release from sulfane sulphur (precursor of H 2 S) in the homogenates of rat kidneys and other tissues, and increases expression of H 2 S-producing enzymes (CBS, CSE and 3-MST), leading to increased renal and plasma H 2 S levels under pathological conditions (Bilska et al., 2008