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It should be noted that distantly related insect groups, such as the Diptera and the Lepidoptera, may have independently acquired de novo the ability to synthesize VC

Again, the use of Cys residues at the stapling locations is notable as no unnatural amino acids are required and Cys residues can be easily introduced in the desired position

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In Caco-2 cells, GHK-Cu reduces tert-butyl hydroperoxide-induced ROS by almost 50% at 10 M concentration