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Cannabis, particularly when smoked regularly, has been associated with cannabinoid hyperemesis syndrome (CHS) , a condition characterised by cyclical severe nausea and vomiting
The dose escalation schedule used in clinical trials followed a structured, gradual titration approach designed to improve tolerability and reduce gastrointestinal side effects
Importantly, while RCTs consistently demonstrate robust short-term glycemic improvements, real-world data suggest that long-term treatment continuity remains a major challenge
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To determine patent expiration dates, the researchers used a global database of pharmaceutical patents and cross-checked the findings against regional patent registries