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These are complementary strategies that address weight through different biological pathways -- CagriSema through dual appetite suppression mechanisms, retatrutide through appetite suppression plus increased energy expenditure

Key gap: no human trial has been published, and no human pharmacokinetic study is widely available

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only the target dose numbers change

However, these in vitro and animal studies lack validation in human SLE patients, and the optimal butyrate concentration for clinical application remains undetermined