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The extent of direct blood-brain barrier penetration varies by agent

Acknowledgements The authors thank Prof

Bezin, J., Gouverneur, A., Pnichon, M., Mathieu, C., Garrel, R., Hillaire-Buys, D., Pariente, A., & Faillie, J

46 That dedicated kidney outcomes study, involving over 3500 patients with both T2D and established chronic kidney disease, demonstrated that once-weekly subcutaneous semaglutide 1.0 mg significantly reduced the primary composite renal outcome (including kidney failure onset, a 50% persistent decline in estimated glomerular filtration rate (eGFR), or renal/cardiovascular death) compared with placebo

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A., & Jerlhag, E