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World Journal of Gastroenterology (2016)

Rezende MC, Palma MI, Chaves BS, Fontes PA, Rocha JG, Rezende JRP

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Within the ARC two distinct sets of neurons have opposing effects on appetite

* *In a 68- and 72-week clinical trial studying Wegovy (2.4 mg) in patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15% and 20%, when paired with diet and exercise changes (compared to 2.4% and 3.1%, respectively, with diet and exercise alone)

Nausea typically peaks during dose increases and subsides within 3-5 days