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doi: 10.1185/030079906X162746 12 RhrbornDWronkowitzNEckelJ

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95% CI, 0.62-1) and those aged 65 years or older (HR = 0.72

Lipotoxic ER stress also contributes to IR, which was mechanistically associated with the lipotoxic inhibition of IRE1 and its downstream transcription factor XBP1 via Bax inhibitor-1 (BI-1), an ER membrane protein [63]