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The creatinine has nowhere to go, so its levels in the bloodstream begin to rise

Nat Commun 12:279

He also hypothesized that senolytic drugs can selectively eliminate senescent cells from patients with SLE and rejuvenate these tissues, improve organ function, and promote disease dormancy

NADPH levels are maintained by G6PD, meaning in G6PD-deficient RBCs, GSH is not restored to adequate levels under oxidative stress, leading to a buildup of free radicals and insoluble hemoglobin within the cell

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