Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White) F1 mice suppress in vitro production of antibodies to DNA
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EHMT2/G9a stood out as a potential target: it is an epigenetic regulator expressed in immune cells, including macrophages, and its previously determined half maximal effective concentration (EC 50 ) (PubChem AID: 504332) matches the effect range (10100 M) seen in our study 39