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K.HongM.BaekJ.ChoiH.ZhaoW.JungY.et al (2014)

Some individuals experience tiredness or heightened hunger, particularly with MK-677

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In a randomized controlled trial in 48 breast cancer patients without anemia who were undergoing hormonal therapy, treatment with 3000 mg of Ganoderma lucidum (reishi) spore powder daily for four weeks resulted in significant improvements in fatigue and physical well-being, as well as in anxiety, depression, and overall quality of life (Zhao 2012)

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These patients should use b12 supplementation regardless of whether their semaglutide formulation includes it