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FIGURE 3 Effect of folic acid on the expression of heme oxygenase 1 protein in the kidney of lead exposed rats The expression of HO-1 protein in the kidney was detected by immunofluorescence

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One feature making this trial particularly interesting is the choice of medicine

The vascular endothelium modulates muscle perfusion through NOmediated vasodilation, whereas skeletal muscle subsequently secretes myokines such as interleukin-6 (IL-6), irisin, and vascular endothelial growth factor (VEGF), which influence endothelial cell activity, angiogenesis, and vascular remodeling (16, 17)

This post hoc analysis of the 24-week SLIM LIVER single-arm trial (ACTG A5371, No