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Also, peptides related to BMPs or those related to cells types or conditions distant to bone healing or bone cells were excluded from the selection process as these were out of the scope of the manuscript

Common modification methods include the introduction of non natural amino acids, cyclization of peptide chains, and glycosylation of peptide chains

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Mice with genetic ablation of the adipocyte clock display enhanced weight gain during high-fat-diet (HFD) feeding, increased visceral adiposity and arrhythmic food intake with increased light-phase feeding 11

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However, because AOD9604 is often selfadministered outside clinical settings, the safety margin can vary depending on sourcing, dosing accuracy, and overall protocol design