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For instance, *db/db* mice, which lack a functional leptin receptor, and *ob/ob* mice, which are leptin-deficient, are foundational for studying the leptin axis

Goff SP

Iceland scientists want to drill a hole straight into a reservoir of molten magma about a mile underground

Lancet 2 , 423 (1979)

Even if we could specifically block the IGF-1R and not IR, unwanted effects may arise such as glucose dysregulation and diabetes due to the inhibition of hybrid IGF-1R/IR receptors