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Ndufs2 KO adipocytes showed reduced expression of the pathways involved in fatty acid metabolism, insulin signalling, peroxisome proliferator-activated receptor (PPAR) signalling and lipolysis, along with activation of oxidative stress, inflammatory and glycolytic programmes

Using advanced tracer methodologies, the researchers identified a fascinating metabolic phenomenon they termed "brain glucose steal." Due to systemic mitochondrial impairment, non-brain organs were essentially stealing glucose intended for the central nervous system, starving the brain of energy and driving cognitive dysfunction

For instance, decreased expression of lncRNA H19 increases ROS via the MAPK/ERK signaling pathway (Ding et al., 2018), while the reduction of lncRNA growth arrest specific 5 in melanoma enhances intracellular ROS (Chen et al., 2019)

10.1016/j.bbamcr.2018.02.010 4 BellezzaI.TucciA.GalliF.GrottelliS.MierlaA

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