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SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

doi: 10.1016/j.clnesp.2022.04.019 246 ArreolaRQuintero-FabinSLpez-RoaRIFlores-GutirrezEOReyes-GrajedaJPCarrera-QuintanarLet al

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(2019) further demonstrated that recombinant human GLP-1 (rhGLP-1) suppresses epithelial apoptosis and mitigates tubulointerstitial fibrosis via the PKA/PKC signaling pathway (Yin et al., 2019)

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The amount of cytochrome c oxidase negative muscle fibers in treated mice decreased by 30%, the citrate synthase activity in muscle as a marker of mitochondrial biogenesis was doubled, liver lipid levels were restored and muscle mitochondrial ultrastructure was normalized (no ragged red fiber-like muscle fibers or mitochondria with distorted structure and cristae on electron microscopy)