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Shear flow or buffeting Shear force from the flow of blood in the vasculature disrupts the interactions between the lymphocyte function-associated antigen 1 (LFA1) ectodomains causing leg separation and favouring the extended open conformation, which can then rapidly bind to intercellular adhesion molecule 1 (ICAM1)

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Gerardi DG, Tinucci-Costa M, Silveira ACT, Moro JV

Cautions: Consult a health care practitioner prior to use if you are pregnant or breastfeeding or have a liver or kidney disease or seizure disorder