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Produced in the liver, glutathione is involved in: Neutralizing free radicals Detoxifying heavy metals and toxins Supporting immune function Regenerating other antioxidants like vitamins C and E Maintaining mitochondrial (energy-producing) function In skin health, glutathione works in three main ways: Reduces oxidative stress that causes inflammation and cellular damage Supports liver detoxification, which helps clear toxins and hormones that may contribute to acne Modulates melanin production by influencing the enzyme tyrosinase, potentially reducing hyperpigmentation When combined with vitamin C, glutathione becomes even more effective

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Patients with MetSR demonstrated statistically significant improvement in depressive symptoms (DCD: SMD = 0.72, 95% CI: 1.41 to 0.03), while non-MetSR conditions showed no significant treatment effect (SMD = 0.57, 95% CI: 1.33 to 0.18)

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