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It works by stimulating insulin release (insulin secretion) when blood sugar levels are elevated, reducing glucagon secretion from the pancreas, and slowing gastric emptying to reduce appetite and enhance feelings of fullness

Clinical trials show semaglutide produces 15-22% body weight loss over 68 weeks, while metformin typically results in 2-3 pounds per year in non-diabetic patients

These medications are indicated for diabetes and the long-term treatment of obesity

High blood sugar can be a problem as it may cause organ damage, bone and joint problems, and damage to blood vessels

Pramlintide reduces postprandial glucose excursions when added to insulin lispro in subjects with type 2 diabetes: a dose-timing study

While a one-repetition maximum is a classic measure of muscle strength, it is not recommended unless the individual is highly trained