Key symptoms that warrant medical attention include: Jaundice : Yellowing of the skin or whites of the eyes, indicating elevated bilirubin levels Dark urine : Brown or tea-colored urine that persists beyond initial hydration status Pale or clay-colored stools : Suggesting impaired bile flow Persistent abdominal pain : Particularly in the right upper quadrant where the liver is located Unexplained fatigue : Severe tiredness that interferes with daily activities Nausea and vomiting : Especially when persistent and unexplained by other causes Loss of appetite : Significant decrease in food intake beyond expected effects of the medication Easy bruising or bleeding : Potentially indicating impaired liver synthetic function Emergency warning signs requiring immediate medical care include mental status changes or confusion, significant bleeding, and severe abdominal pain with fever
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However, the complexity of macrophages in vivo, which represents a continuum of cellular states with distinct features and functions, is not fully reflected by this phenotype
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