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Compound 17 was ordered from a commercial supplier (www.wuxiapptec.com) and wt PV2 VLP and CP17 were mixed at a molar ratio of 1:2500 as used in the CVB3-CP17 and CVB4-CP48 studies 28,29 and incubated at 4 C overnight

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Inspect the packaging immediately upon arrivalif cold packs are completely thawed and warm to the touch, or if the box exterior feels warm, the vial may have experienced temperature excursion above 8C