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147 Overexpression of miR-144-3p could downregulate the GSH/GSSG ratio, increase the levels of ROS, Fe 2+ , and ACSL4, promote ferroptosis and thus reduce the metastasis of osteosarcoma cells, while high expression of ZIB1 plays the opposite role, 147 indicating that miR-144-3p and its downstream ZIB1 are involved in the development and metastasis of osteosarcoma mainly by interfering with iron metabolism and redox homeostasis

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First, it stimulates vascular endothelial growth factor expression

Genetics All forms of cystinosis are caused by biallelic, pathogenic variants in the CTNS gene located on chromosome 17p21 and identified in 1998 [7]