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Most healthcare systems recommend informing your pregnancy care team of the exposure, though brief unintended exposure during early pregnancy carries minimal documented risk

MTHFR and the Methylation Cycle Normal role: MTHFR converts 5,10-methylene-tetrahydrofolate into 5-methyltetrahydrofolate (5-MTHF), the active folate required for homocysteine methionine conversion

These foundations become even more important with long-term use

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Some trials and reviews suggest potential benefits for: Fasting glucose Insulin resistance markers Triglycerides Total cholesterol Waist circumference Body weight, modestly That is not nothing