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According to the UK SmPC, the inactive ingredients (excipients) in Mounjaro include sodium chloride, sodium phosphate dibasic heptahydrate, sodium hydroxide and hydrochloric acid (for pH adjustment), and water for injections

Who Is Most at Risk for B12 Deficiency

Common adverse effects include: Injection site reactions pain, redness, swelling, or bruising at the intramuscular injection site Gastrointestinal disturbances nausea, diarrhoea, or abdominal discomfort Headache and dizziness particularly following initial doses Skin reactions including rash, pruritus, or acne-like eruptions Flushing temporary redness of the skin Chromaturia red-coloured urine (harmless but can cause concern if unexpected) Less common but more serious reactions include: Hypersensitivity reactions ranging from mild urticaria to anaphylaxis (rare but potentially life-threatening) Hypokalaemia particularly during initial treatment when rapid cell production occurs [5] [16] Temporary changes in blood counts during correction of deficiency Interference with laboratory tests primarily with high-dose IV hydroxocobalamin used for cyanide poisoning, not typically with standard 1mg IM replacement doses Cautions and contraindications: Hypersensitivity to cobalt or vitamin B12 Cyanocobalamin should be avoided in Leber's hereditary optic neuropathy [2] [17] Chloramphenicol may reduce the haematological response to B12 therapy Patients receiving B12 injections outside clinical necessity face unnecessary risks without proven benefit

(1) Lipolysis is a term to describe the process through which stored fats or triglycerides in fat cells are broken down into glycerol and free fatty acids, which may be used as an energy source by other cells

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Although originally intended for individuals with type 2 diabetes, metformin has proven effective in pregnancy programsespecially for women with PCOS or obesity