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All proposals received after the updated matrix is published will be evaluated under the new framework

In a clinical trial involving patients with advanced melanoma, VPA increased cancer cells' sensitivity to chemotherapy, caused growth arrest, induced apoptosis in glioma cells, and enhanced survival rates (Rocca et al., 2009)

In Bca cells treated with brusatol, CHAC1 expression significantly rises, leading to GSH depletion, ROS buildup, and increased lipid peroxidation, which are key features of ferroptosis

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