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While these conversations have fueled demand, many of the claims circulating online remain largely unproven in human studies

These dysfunctions may arise from impaired pyruvate dehydrogenase (PDH) function identified in muscle cells (390) and serum (184), as well as reduced plasma coenzyme Q10 (CoQ10) levels in ME/CFS blood and plasma (372, 391) that is inversely associated with fatigue severity (391)

GI dysmotility remains a major therapeutic gap

This could potentially interfere with the healing cascade in the specific area of injury, so its still a conflicting mechanism.

Cell 161 , 15271538 (2015)

Biochim Biophys Acta Mol Basis Dis (2021) 1867(10):166182