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Cellular uptake was evaluated in SH-SY5Y neuroblastoma and hBMECs using confocal laser scanning microscopy and flow cytometry revealing 5.4X higher uptake of lactoferrin-conjugated nanoparticles as compared to non-conjugated PLGA NPs following 5 h of exposure

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If levels drop below 300 pg/mL, supplementation is warranted even without symptoms