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The tertiary structure of the peptide, the 3D shape that allows it to bind to GIP and GLP-1 receptors, starts to unfold

Treatment should be discontinued after 12 weeks at the 3.0 mg dose if weight loss of at least 5% of initial body weight has not been achieved

For Ozempic, eructation is not listed among adverse reactions occurring in 5% of patients in clinical trials, suggesting a lower incidence at the diabetes treatment doses

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If you have persistent GI intolerance, certain comorbidities, or you personally value a moderate weight change over maximal loss, a clinician might target a mid-range maintenance dose