Cytotoxicity and pro-oxidant effects at high doses can also occur
Lack in these vitamins will affect these pathways thus resulting to hyperhomocysteinemia which is related to cardiovascular diseases, bone metabolic complications as well as neuropathies
(1) O P Stanojlovi 1, D P Zivanovi, and V T Susi (2000) The effect of delta sleep-inducing peptide on the EEG and power spectra in rat Indian Journal of Physiology & Pharmacology, 2000 Oct, Volume 44 (Issue 4), Pages 428-34
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10.1002/jcsm.13722 J
Interestingly, the administration of some Lactobacillus species, seems to exert beneficial effects in RA clinical signs, which suggests that different Lactobacilli may have different roles in RA pathogenesis and disease activity modulation (Vaghef-Mehrabany et al., 2014)